Clinical trial protocol review

Find the gaps before they become amendments.

Pre-Flight reads a protocol for missing requirements, contradictions and participant burden, then shows each finding beside the page that supports it.

Review a protocol See how it works

Built for protocol authors and review teams. The final decision stays with people.

The problem

Late protocol changes cost time and money.

45%of substantial amendments were judged avoidable

$535Kmedian direct cost of one Phase III amendment

Tufts CSDD / Getz et al., 2016

Measured performance

A review you can trace.

Measured on seven held-out protocols with 65 injected errors. The live demo protocol is 134 pages. See the evaluation

9×the precision of a bare AI prompt90% vs 10% on our held-out test set

0ungrounded AI citations shown60 rejected before reaching reviewers

31smedian review time30.5 seconds across seven protocols

<1¢median model cost per review$0.0065 across the same seven

25 issues resolvedin one demo revision, with the score moving from 70 to 84

91% fewer false alarmsafter rule fixes on a real amended protocol

200 trial historiesin an exploratory check of an eligibility outlier signal

What we built

From a dense PDF to a useful review.

Rules and four specialist AI reviewers work together. A verifier checks every AI quote against its cited page before it appears. Confidential mode makes no model calls.

Open the review workspace

01
Map the protocol
Parse the PDF, its schedule and key trial details against ICH M11 and SPIRIT 2025.
02
Check the logic
Find missing sections, contradictions, visit conflicts and burden outliers against peer trials.
03
Review the evidence
Open each finding on its source page, accept or reject it, then compare a revision.

Explore the system

How Pre-Flight works together.

Open full diagram

Find the gaps before they become amendments.

A review you can trace.

From a dense PDF to a useful review.

Map the protocol

Check the logic

Review the evidence

How Pre-Flight works together.